Down syndrome
noun
variants
or Down's syndrome
: a congenital condition characterized especially by developmental delays, usually mild to moderate impairment in cognitive functioning, short stature, upward slanting eyes, a flattened nasal bridge, broad hands with short fingers, decreased muscle tone, and by trisomy of the human chromosome numbered 21
called also trisomy 21
Examples of Down syndrome in a Sentence
Recent Examples on the Web
An actor with Down syndrome making his film debut in The Julia Set, Dillard is repped by Gamut Management.
—
Matt Grobar, Deadline, 28 Oct. 2025
The influencer and her husband, Tomas, share one biological child and three adopted from foster care, and their youngest two kids have Down syndrome.
—Zoey Lyttle, PEOPLE, 22 Oct. 2025
In August, agents raided a home in East Oakland and removed seven people, including a teenager with Down syndrome.
—Jakob Rodgers, Mercury News, 22 Oct. 2025
One of the most common was broken or outdated HVAC systems, often an expensive upgrade; freezing or overheated classrooms can be especially hard on students who can’t regulate their body temperatures, such as children with Down syndrome.
—Becca Savransky, Idaho Statesman, 15 Oct. 2025
See All Example Sentences for Down syndrome
Examples are automatically compiled from online sources to
show current usage.
Read More
Opinions expressed in the examples do not represent those of Merriam-Webster or its editors.
Send us feedback.
Matt Grobar, Deadline, 28 Oct. 2025
The influencer and her husband, Tomas, share one biological child and three adopted from foster care, and their youngest two kids have Down syndrome.
—Zoey Lyttle, PEOPLE, 22 Oct. 2025
In August, agents raided a home in East Oakland and removed seven people, including a teenager with Down syndrome.
—Jakob Rodgers, Mercury News, 22 Oct. 2025
One of the most common was broken or outdated HVAC systems, often an expensive upgrade; freezing or overheated classrooms can be especially hard on students who can’t regulate their body temperatures, such as children with Down syndrome.
—Becca Savransky, Idaho Statesman, 15 Oct. 2025
See All Example Sentences for Down syndrome
Cite this Entry
“Down syndrome.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/Down%20syndrome. Accessed 12 Nov. 2025.
Copy CitationLove words? Need even more definitions?
Merriam-Webster unabridged
Share